August 20th, 2016
According to article published in the archives of Neurology research magazine (Arch Neurol. 2010 Feb; 67 (2): 154-60) clinical trial to evaluate the safety and tolerability of Dimebon (latrepirdine) in Huntington’s disease and explore their effects on cognitive function, behavior, and motor symptoms showed positive preliminary results. The clinical trial was a double-blind, multicenter, which participated in 91 patients with mild to moderate Huntington’s disease at 17 centers between United States and England from July 2007 to July 2008. Dimebon (latrepirdine) was administered 20 mgs 3 times a day. The primary objective was to assess the tolerability, defined as the ability to complete the assigned dose study, the secondary variable in study included changes in the score from the basal line scale unified of disease of Huntington (UHDRS), the MMSE test and cognitive scale of Alzheimer.
The results obtained were as follows: Dimebon (latrepirdine): was well tolerated (87% of the) patients who manage Dimebon completed the study vs. 82% in the Group placebo control), the rate of adverse events was comparable in the two groups (70% in the Dimebon group) and 80% in the Placebo group. Treatment with Dimebon (latrepirdine) has resulted in an improvement in the average of the score of MMSE test compared with the placebo group. No significant effect in the score from the basal line of scale unified of Huntington disease (UHDRS). Conclusion in this study that the Administration during a short period of Dimebon (latrepirdine) is well tolerated in patients with Huntington’s disease and may have a beneficial effect at the cognitive level, so a trial more big this justified in the population of patients with Huntington’s disease.
August 19th, 2016
In the regulated cases which need a communication or responsible declaration or the granting of a licence for an activity for an indefinite time, the duration of the provision of the service may only limit when: 1) responsible for declaration or authorisation is renewed automatically, 2) only subject to continued compliance of the requirements, 3) that the number of available authorisations is limited by the scarcity of natural resources or unambiguous technical impediments4) that such limitation could be justified by the existence of an overriding reason of general interest. In relation to the preceding paragraph, the provision of services only may limit to a single part of the Spanish territory for reasons of order, security, or public health or for the protection of the environment. All such restrictions must always be motivated According to criteria of proportionality and non-discrimination. As we have said before, the providers of services of a Member State shall have the right to provide such service in Spain, except with the exceptions discussed above or in those cases restricted by the relevant sectoral regulations. Without prejudice to the above, as a general rule, not may be limitations such as the need that the lender should: 1) settle in Spain, 2) authorization to a local authority, 3) entered in a register, 4) to register in a school or professional association, 5) obtain a specific identification document, 6) the use of certain equipment or materialsexcept for reasons of health and safety at work. As a result of all this has been modified the law 30/1992, of 26 November, legal regime of public administrations and of the procedure Administrative common, stating that in the event any public administration need to restrict the development of an activity, they must do so taking far less restricting, motivating and justifying their actions, in order to protect a public interest, avoiding any discrimination between service providers difference of course.
August 13th, 2016
The figure of ' ' chefe' ' if it modernized, thus, in some companies, it has one more malleable politics so that the employees participate of the organizacional life with ideas, suggestions, and even though critical that will serve for the development of the same ones. One more time it is proven the necessity of adaptation of the thought and opinion of the managers on the question of ' ' to learn aprender' ' , in view of that this capacity can be conquered by any employee, and not only for them. The paper of the Administrator of today is very flexible, that is, is necessary that the same ones are always intent to the market and its changes, so that thus they obtain to follow the trends and new methods that are being developed and used in the market. The current economic scene is marked by the Globalization, that has as main focus the free circulation of good through the integration of the world-wide economies (Saints, 1993). As consequence, the competition is ampler, after all, now the company does not concur only with its local competitors, but also with others of any part of the world. In the courses of Administration this thematic one is boarded in order to prepare the future Administrator for the work market, therefore it also will concur the work vacant with professionals of the world all. Of this form he is possible to observe that the Administrator is a professional who has a great field of performance, being able to develop its knowledge in companies of all the sizes, is public or private they, independent of the performance branch. It has a very great fan of options for competent and qualified professionals, whom they know to develop activities in set with other collaborators and not only add value for itself, in a tacit knowledge, but that they have capacity to learn to transcribe this explicit, so that this if also transforms into value for the organization, and either used to advantage knowledge in the globalizada age where we live.